Forsøksdyr: Effects of Ghrelin hormone injection on 18F- Fludeoxyglucose ( [18F]-FDG) uptake in rat brain

Godkjenningsdato 01.05.2018

Ghrelin hormone is mainly secreted by the stomach and its acylated form (acyl-ghrelin) promotes food intake primarily through activation of the growth hormone secretagogue receptor 1A (GHSR-1A.). GHS-R is a G-protein-coupled receptor present in high density in the hypothalamus and pituitary gland. The presence of GHS-R has also been reported in extrahypothalamic areas of the CNS including the cerebral cortex, dentate gyrus, CA2 and CA3 regions of the hippocampus, parafascicular thalamic region, substantia nigra, ventral tegmental area, raphe nuclei and dorsal vagal complex (Ferrini F et al., 2009). Ghrelin levels increase during food deprivation in
animals and prior to meals in humans, and may serve as a critical signal to induce hunger during
fasting. Peripheral or direct administration of ghrelin into the brain stimulates feeding (Tschöp M et al., 2000). Ghrelin induces synaptic plasticity in the midbrain as well as the hippocampus where ghrelin has been implicated in learning . Apart from stimulating food intake and promoting
weight gain, ghrelin has been implicated in glucose metabolism (Sun Y et al., 2006). Our aim is to perform pilot study in order to observe the effects of Ghrelin hormone injection on 18F- Fludeoxyglucose ( [18F]-FDG) uptake in different region of the rat brains. This study can provide us information about impact of Ghrelin hormones in region specific energy metabolism.