Forsøksdyr: Understanding the pharmacokinetics of compounds v, w, x, y and z in Atlantic salmon


Godkjenningsdato 01.04.2020

Godkjenningsperiode 05.04.2020-05.04.2022

FORSØKETS FORMÅL: The objective of the trial is to document the pharmacokinetic (PK) parameters of selected compounds in Atlantic salmon. This is a trial planned at the preliminary feasibility phase of the project and therefore the scope of the trial is limited.


FORVENTEDE SKADEVIRKNINGER PÅ DYRENE.

The experiment will be classified as severe overall as the study involves single administration of a dose that may cause adverse effects. The compounds v, w, x, y and z are already tested for safety in Atlantic salmon through bath but a single dose administration through feed has not been tested before. Therefore this study should be considered as coming under *forsøksdyrforskriften Vedlegg B Del III punkt 3a*.

FORVENTET VITENSKAPELIG ELLER SAMFUNNSMESSIG NYTTEVERDI:
Parasite L is a persistent threat to the salmon farming sector and results in large scale economic losses. Additionally, animal welfare is also compromised when the parasite number exceed a certain limit. It is expected that if found promising in this study, these test compounds could be further developed as potential therapeutic agents against parasite L.

HVOR MANGE OG HVA SLAGS DYR SOM SKAL BRUKES: 310 Atlantic salmon smolts will be used in this study


HVORDAN KRAVENE OM ERSTATNING, REDUKSJON OG FORBEDRING SKAL ETTERLEVES

ERSTATNING: A study on live fish needs to be done because sutiable invitro models to determine the pharmacokinetics (PK) of chemicals in fish are not available yet .

REDUKSJON: The number of fish used in this study is the minimum recommended fish number for analysis based on experience with analysis of similar compounds (approximately 5 fish per sampling point)

FORBEDRING: Fish will be euthanized by anesthetic overdose/ blow to the head for sampling. Fish will be handled gently according to internal SOPs at ILAB. Use of humane endpoint (euthanizing of moribund fish) will reduce the suffering for individual fish if some adverse effect of challenge or treatment surfaces.

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