Forsøksdyr: Optimizing emulsions for developing more efficient vaccines for Atlantic salmon (Salmo salar L.)


Godkjenningsdato 10.04.2020

Godkjenningsperiode 01.06.2020-01.06.2024

1.Formål
The goal of the project is to Improve fish vaccine efficiency and safety by increasing antigen availability and providing specific nutrients to the fish immune system by optimising the vaccine emulsion

2 Skadevirkninger
The vaccine injection will be carried out under full anaesthesia and will not cause pain or discomfort. The injection of a vaccine with an oil adjuvant is expected to lead to an inflammatory reaction at the injection site. The inflammatory reaction is necessary to achieve immunological protection. All sampling of tissues will be done after the fish is killed by an overdose of anaesthesia.

3 Forventet nytteverdi
To Improve fish vaccine efficiency and safety by increasing antigen availability and providing specific nutrients to the fish immune system. And to contribute to better fish welfare by reducing the number of side effects caused by different adjuvants.

4 Antall dyr og art
The number of fish to be used is 1800 Atlantic salmon (Salmo salar L.)

5 Hvordan etterleve 3R
The number of animals are reduced to the minimum necessary to achieve statistically significant results